SINGLE SPINAL MOTONEURONS EXCITABLE FROM TWO DIFFERENT ANTIDROMIC PATHWAYS
نویسندگان
چکیده
منابع مشابه
Extracellular Potentials from Single Spinal Motoneurons
Extracellular action potentials found close to the surface of motoneurons are related to the intracellular spikes. Evidence is cited to support the assumption that the extracellular spikes have the same time course as the membrane current at the site of recording. Simultaneously recorded intracellular and extracellular spikes are compared. Intracellular spikes are transformed, by means of a cir...
متن کاملCollision of two action potentials in a single excitable cell.
BACKGROUND It is a common incident in nature, that two waves or pulses run into each other head-on. The outcome of such an event is of special interest, because it allows conclusions about the underlying physical nature of the pulses. The present experimental study dealt with the head-on meeting of two action potentials (AP) in a single excitable plant cell (Chara braunii internode). METHODS ...
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ALS (amyotrophic lateral sclerosis) is an adult-onset and deadly neurodegenerative disease characterized by a progressive and selective loss of motoneurons. Transgenic mice overexpressing a mutated human gene (G93A) coding for the enzyme SOD1 (Cu/Zn superoxide dismutase) develop a motoneuron disease resembling ALS in humans. In this generally accepted ALS model, we tested the electrophysiologic...
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Severe spinal cord injury and diseases involving motoneuron loss cause miserable outcomes in clinical settings, and no therapy can reverse the patients[ disabilities in the final stages of the disease. Cell replacement therapy, however, is a possible approach for treating irreversible damage and loss of spinal motoneurons. Embryonic stem cells have been considered for use as graft cells and ana...
متن کاملMotoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons.
Induced pluripotent cell-derived motoneurons (iPSCMNs) are sought for use in cell replacement therapies and treatment strategies for motoneuron diseases such as amyotrophic lateral sclerosis (ALS). However, much remains unknown about the physiological properties of iPSCMNs and how they compare with endogenous spinal motoneurons or embryonic stem cell-derived motoneurons (ESCMNs). In the present...
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ژورنال
عنوان ژورنال: The Japanese Journal of Physiology
سال: 1960
ISSN: 1881-1396,0021-521X
DOI: 10.2170/jjphysiol.10.121